(I stopped the first test midway due to painful slowness)
After installing my new bargain basement ($49.99 after rebate) OCZ Trio N150 240GB, the read speeds were abysmal. I used AOMEI Backupper to clone the current OS.
First I fixed "over provisioning", which is simply leaving 7-10% unallocated space on the hard drive. I did not screen shot the results but it improved 10 to 20 MB/s. There is some controversy to this.
Then I fixed the alignment. I used AOMEI Partition Assistant to fix the alignment. The results were impressive. Minitool Partition Wizard also works for alignment.
This was done in my bottom feeding $250 Dell Optiplex 7010 Mini Tower i5. Dell disabled RAID in BIOS so I question if a PCIe NVMe would boot. Decided simple SATA SSD was sufficient.