If Microsoft Office does not associate properly with an xlsx file, here is a little program that will fix it. It will fix other associations also but I recently had a problem after installation of Office 2010 and later uninstalling Office 2003.
Program here: Nice little stand alone program. I suppose there is a way to fix the association without the program but it defied my attempts and I ran out of patients.
Go to "File Type Settings" and on the bottom left choose "Change 'Open with' programs. Then find xlsx extension and choose next. Now Excel 2010 should appear as a choice. Windows refused to show Excel 2010 as a choice without this little program and manually locating Excel and choosing it from within Windows would not stick so this little guy is doing something special.
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