I decided to set up Medicate again just for fun. I did it awhile ago and, yes, Defender drove me crazy. Since then with Sordum Defender Control I thought I 'd try it again to see what's new.
You need to download Medicat and the installer separately. Don't even think about torrent, it took 24 hours.
I put the Medicat files in my Defender "excluded" folder
I installed Ventoy onto the destination drive.
This is not necessary, Medicat will prepare the drive with Ventoy.
Install has a "format or not" button for if Ventoy exists or not.
So you can have a Ventoy favorite and add Medicat to it.
I dropped a temporary link to the drive into Defender Exclusion just for kicks.
Now shut down Defender With Sordum Defender Control.
Run the installer.
It's an interesting process. Medicat verifies all the files after install (whatever that means).
While Defender is off, start the Portable Apps menu, options auto upgrade. Close and reopen to upgrade the apps.
It is a monster which can never be plugged into a Windows system with Defender running.